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br As regards the contributions of
2019-10-18
As regards the contributions of the different particle metrics, the ef-fect of the particle mass (PM10) to the estimated ER value resulted neg-ligible, then the risk is mostly affected by the particle surface area metrics (i.e. by UFPs). This finding was somehow expected since similar results were
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Epirubicin HCl br Introduction br Cancer is
2019-10-16
1. Introduction Cancer is a key public health problem worldwide and it is the second reason of death in the USA. In 2017, 1688,780 recent cancer cases and 600,920 cancer deaths are projected to happen in the United States. For all sites incorporated, the cancer infection rate is 20% higher in m
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br Abbreviations ADC antibody drug conjugate mAb monoclonal
2019-10-15
Abbreviations: ADC, antibody drug conjugate; mAb, monoclonal antibody; ADS, antibody drug system; Fc, fragment crystallisable; FcBM, Fc-binding module; PEG, polyethylene glycol; Trz, Trastuzumab; Rtx, Rituximab; TubA, Tubulysin A; DAR, drug-antibody ratio; SpA, staphylococcal Protein A; SpG, strep
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br Flow cytometric analysis of CSC surface markers identifie
2019-10-15
3.2. Flow cytometric analysis of CSC surface markers identified as CD44+/ CD24− cells To verify whether that the DSCs population selected after 72 h of different concentrations of the applied chemotherapies possessed the hypothesized chemotherapeutic-resistant phenotype with the char-acteristi
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br To analyst pH responsive
2019-10-14
To analyst pH-responsive drug release effect, pH = 4.35 and pH = 7.4 PBS were prepared. To calculate the loading, absorbance of the supernatant obtained by centrifugation was analyzed by UV–vis spectrum of 480 nm. In vitro release experiments were as follows: FeSiAuO-DOX-PEG was soaked in 10 mL PBS
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Oxaliplatin br A major new discovery driven by the developme
2019-10-14
A major new discovery driven by the development of the network map was the identiÞcation of RORg as a key immuno-regulatory pathway hijacked in pancreatic cancer. This, together with prior work implicating RORg in prostate cancer models (Wang et al., 2016), suggests that this pathway may not be re
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br Hijacked Immuno regulatory Programs as Direct Regulators
2019-10-14
Hijacked Immuno-regulatory Programs as Direct Regulators of Pancreatic Cancer Cells Ultimately, the power of such a map is the ability to identify and understand key new functional dependencies. Thus, we used the network map as a framework to select an integrated gene set based on the transcrip
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br Conclusions and future research directions br
2019-10-12
7. Conclusions and future research directions Selecting an effective treatment plan for breast cancer where a large number of conflicting criteria and treatment options exist is a complex decision-making process. Furthermore, every patient’s case is unique, requiring a patient-specific treatmen
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br Neurological symptoms concurrent BM
2019-10-10
Neurological symptoms, concurrent BM and the result of TCT were not significantly related to OS in our study. However, 105 patients (34.9%) did not perform the CSF TCT in the present study, potentially lead to the negative result of TCT. It is regrettable that CSF TCT was not widely performed in t
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br Table br Patient type
2019-10-08
Table 2 Patient type based on duration of the treatment. Patient type Expected treatment time (min) No. of 20-min slots 2.5. Mathematical model general description The infusion area is a complex system that requires a variety of resources and a logical sequence of steps. Generally
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br Conclusion br In summary
2019-10-07
Conclusion In summary, we have developed a cationic polyfluorene based amphiphilic, fluorescent polymer nanosphere probe for cancer cell targeting and imaging by fluorescence “turn on-turn off” mechanism. The CPF polymer nanoprobes have significant pH dependent Fig. 7. Effect of diverse potent
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br TGF signaling in GC cells Yu et al
2019-10-07
TGF-β signaling in GC Meropenem (Yu et al., 2014). Inactivation of Hippo signaling leads to pro-proliferation and anti-apoptosis, which increases cancer risk (Zeng and Hong, 2008). Chronic Helicobacter pylori infec-tion, a factor associated with the highest risk of developing GC, con-tributes to
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Biochemical Engineering Journal br cells The corresponding d
2019-10-02
Biochemical Engineering Journal 148 (2019) 152–161 cells. The corresponding doubling time of 45 ± 1 h was consistent with the reported specific growth rate of 0.015 h-1 for MCF-7 cells [45]. In contrast, the growth of NIH-3T3 cells was inhibited by about 10-30% when cocultured with MCF-7 cells
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br Tumors were minced and dissociated
2019-10-01
Tumors were minced and dissociated using Liberase (Roche, Basel, Switzerland) at 0.04 mg/mL for 2 h and then passed through a 0.45-mm nylon mesh to obtain the single cell suspension. For the detection of CD4+ and CD8+ T cells, separated splenic or tumor cells were washed with PBS and stained with
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br Corresponding author br E mail address Richard Meenan
2019-10-01
Corresponding author. E-mail address: [email protected] (R.T. Meenan). qualified health centers (FQHCs) remain well below those of non-FQHC populations (National Colorectal Cancer Roundtable, 2018). Fecal im-munochemical testing (FIT) may be a low-cost and effective population-based