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br Flow cytometric analysis of CSC surface markers identifie
2019-10-15
3.2. Flow cytometric analysis of CSC surface markers identified as CD44+/ CD24− cells To verify whether that the DSCs population selected after 72 h of different concentrations of the applied chemotherapies possessed the hypothesized chemotherapeutic-resistant phenotype with the char-acteristi
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br To analyst pH responsive
2019-10-14
To analyst pH-responsive drug release effect, pH = 4.35 and pH = 7.4 PBS were prepared. To calculate the loading, absorbance of the supernatant obtained by centrifugation was analyzed by UV–vis spectrum of 480 nm. In vitro release experiments were as follows: FeSiAuO-DOX-PEG was soaked in 10 mL PBS
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Oxaliplatin br A major new discovery driven by the developme
2019-10-14
A major new discovery driven by the development of the network map was the identiÞcation of RORg as a key immuno-regulatory pathway hijacked in pancreatic cancer. This, together with prior work implicating RORg in prostate cancer models (Wang et al., 2016), suggests that this pathway may not be re
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br Hijacked Immuno regulatory Programs as Direct Regulators
2019-10-14
Hijacked Immuno-regulatory Programs as Direct Regulators of Pancreatic Cancer Cells Ultimately, the power of such a map is the ability to identify and understand key new functional dependencies. Thus, we used the network map as a framework to select an integrated gene set based on the transcrip
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br Conclusions and future research directions br
2019-10-12
7. Conclusions and future research directions Selecting an effective treatment plan for breast cancer where a large number of conflicting criteria and treatment options exist is a complex decision-making process. Furthermore, every patient’s case is unique, requiring a patient-specific treatmen
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br Neurological symptoms concurrent BM
2019-10-10
Neurological symptoms, concurrent BM and the result of TCT were not significantly related to OS in our study. However, 105 patients (34.9%) did not perform the CSF TCT in the present study, potentially lead to the negative result of TCT. It is regrettable that CSF TCT was not widely performed in t
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br Table br Patient type
2019-10-08
Table 2 Patient type based on duration of the treatment. Patient type Expected treatment time (min) No. of 20-min slots 2.5. Mathematical model general description The infusion area is a complex system that requires a variety of resources and a logical sequence of steps. Generally
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br Conclusion br In summary
2019-10-07
Conclusion In summary, we have developed a cationic polyfluorene based amphiphilic, fluorescent polymer nanosphere probe for cancer cell targeting and imaging by fluorescence “turn on-turn off” mechanism. The CPF polymer nanoprobes have significant pH dependent Fig. 7. Effect of diverse potent
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br TGF signaling in GC cells Yu et al
2019-10-07
TGF-β signaling in GC Meropenem (Yu et al., 2014). Inactivation of Hippo signaling leads to pro-proliferation and anti-apoptosis, which increases cancer risk (Zeng and Hong, 2008). Chronic Helicobacter pylori infec-tion, a factor associated with the highest risk of developing GC, con-tributes to
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Biochemical Engineering Journal br cells The corresponding d
2019-10-02
Biochemical Engineering Journal 148 (2019) 152–161 cells. The corresponding doubling time of 45 ± 1 h was consistent with the reported specific growth rate of 0.015 h-1 for MCF-7 cells [45]. In contrast, the growth of NIH-3T3 cells was inhibited by about 10-30% when cocultured with MCF-7 cells
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br Tumors were minced and dissociated
2019-10-01
Tumors were minced and dissociated using Liberase (Roche, Basel, Switzerland) at 0.04 mg/mL for 2 h and then passed through a 0.45-mm nylon mesh to obtain the single cell suspension. For the detection of CD4+ and CD8+ T cells, separated splenic or tumor cells were washed with PBS and stained with
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br Corresponding author br E mail address Richard Meenan
2019-10-01
Corresponding author. E-mail address: [email protected] (R.T. Meenan). qualified health centers (FQHCs) remain well below those of non-FQHC populations (National Colorectal Cancer Roundtable, 2018). Fecal im-munochemical testing (FIT) may be a low-cost and effective population-based
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br Fig A TEM images of GO MGO
2019-09-25
Fig. 3. (A) TEM images of GO, MGO, and PMGO. (B) EDS spectra of GO, MGO, and bPEI-MGO. (C) UV–vis spectra of GO, MGO, bPEI-MGO, and PMGO; the absorbance peak at 680 nm is attributed to PB. (D) Magnetic hysteresis curves of GO, MGO, bPEI-MGO, and PMGO nanocomposites at room temperature; the inset i
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br The outline of the paper
2019-09-24
The outline of the paper is as follows. In Section 1, we present the experimental results and the main features of their PDE-based counterpart. In Section 2, we introduce the full model, whose lin-ear stability analysis is performed in Section 3. Numerical simu-lations of the model are given in Se
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br Co first authors br
2019-09-23
1 Co-first authors. Fig. 1. (a) Schematic illustration of the synthetic procedure for MFNP and (b) the nanoplatform integrating dual-mode MRI, drug delivery, and ROS generation abilities for cancer diagnosis and therapy. clearance from the body. As previously reported [24,25], intracellul