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br Furthermore we analyzed multiple
2020-08-18
Furthermore, we analyzed multiple additional samples from recurrent ovarian cancer disease (Figure S8). The triple treatment showed again a significant reduction of cell viability, 3D-colony formation in short- and long-term experiments, and apoptosis measurements by Annexin staining (Figure S8, A
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br Discussion br Despite several decades of investigation in
2020-08-18
4. Discussion Despite several decades of investigation into biology and treatment of PC, there is still a lack of deep understanding of the causes and pa-thogenesis of PC and more effective therapeutics, making PC one of the most lethal malignancies. Recent findings on the association of dysr
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br The number of referrals correlates with
2020-08-18
The number of referrals correlates with socioeconomic status (SES),3 which is not surprising given that cancer of the head and neck is known to be more prevalent in patients from lower-status groups.4 However, to our knowledge, the association between SES and referrals on the two-week path-way has
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br Interstitial lung disease br Histology br Driver mutation
2020-08-18
Interstitial lung disease Histology Driver mutations M factor No. of metastatic organs Metastasis within the chest cavity Bone metastasis Brain metastasis Liver metastasis Adrenal gland metastasis Lymph node metastasis Muscle metastasis Skin metastasis CI: co
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br Results As of June patients were
2020-08-12
Results: As of June 2018, 11 patients were recruited. One was excluded from the analysis for presenting severe toxicity, suggestive of dihydropyrimidine dehydrogenase (DPD) defi-ciency, after the first chemotherapy cycle. All others completed the treatment. Two patients presented toxicity grade 3/
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br Patient summary In this study we examined
2020-08-12
Patient summary: In this study, we examined the effect of androgen deprivation therapy (ADT) for Gleason 8 (Grade Group 4) versus Gleason 9–10 (Grade Group 5) prostate cancer. We found that Gleason 9–10 disease may derive a smaller survival benefit from ADT than Gleason 8 disease. © 2018 Europe
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br Results and discussion br It is
2020-08-07
3. Results and discussion It is well-known that the formation of phthalocyanine H-aggregates results in a blue-shift of the low-energy Q-band, reduces phthalocya-nines' fluorescence quantum yield and diminishes PDT activity [43–47]. Thus, it was important to evaluate aggregation behavior of th
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br Materials and methods br Cell culture and
2020-08-07
2. Materials and methods 2.1. Cell culture and cell proliferation assay All cell lines used in this study were originally obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). DLD-1, HCT-116 (human colon cancer), MDA-MB-231 (human breast cancer), A375P (human melanoma
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br Keywords br Epithelial ovarian cancer br Human
2020-08-06
Keywords: Epithelial ovarian cancer Human chorionic gonadotrophin Luteinizing hormone Luteinizing hormone (LH)/hCG receptor Overall survival In addition to its critical role during pregnancy, human chorionic gonadotropin (hCG) has been shown to be expressed by various tumor types
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br Fig Kaplan Meier curves for PFS and OS
2020-08-05
Fig. 1. Kaplan-Meier curves for PFS and OS according to antibiotic use in the EIOP. PFS = Progression Free Survival. Atb = Antibiotics. EIOP = Early Immunotherapy Period. OS = Overall Survival. Fig. 2. Kaplan-Meier curves for PFS and OS according to AIER during the WIOP. PFS = Pr
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br Statistical analyses br All the
2020-08-03
2.9. Statistical analyses All the analysis were carried out triplicate and obtained values were expressed as the means ± standard deviation (SD) that was calculated by Microsoft Excel 2016. Statistical analyses were performed using Student’s t-test and ANOVA for two groups and multiples compari
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br Every fraction was weighted and
2020-08-03
Every fraction was weighted and completely dissolved with di-methyl sulfoxide (DMSO; Sigma, St. Louis, MO, USA) at the solubility of 200 mg/mL, and then diluted to the final concentrations of 2, 0.5, and 0.1 μg/mL with adenosine triphosphate tumor chemosensitivity assays (ATP-TCA) kit cell culture
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br Determination of Ab MNP Si binding to CFSC stained
2020-08-02
3.4. Determination of Ab/MNP-Si binding to CFSC-stained Temozolomide and separation from whole blood To evaluate the performance of Ab/MNP-Si in the blood and the ability of the nanoparticle-silane-antibody conjugate to separate cancer cells, after cell staining, different amounts of CFSE-stain
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br LMB Targeting CRC br membrane of ovarian cancer OVCAR
2020-07-30
LMB100 Targeting CRC membrane of ovarian cancer OVCAR-3 cells.4 Since then, MSLN has been studied extensively and found to be highly expressed on many malignancies, including pancreatic adenocarcinoma and mesothelioma.5-8 An RIT targeting MSLN named SS1P was con-structed by fusing the Fv portio
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br In addition to the e ect
2020-07-29
In addition to the effect on endothelial cells, we also examined the effect of ANGPTL6 on tumor cells. Different types of cytokines, che-mokines, and other secretory proteins in the surrounding micro-environment were secreted into the tumor bed, and these proteins not only affect the activity of strom